Angiogenesis

Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.

Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of …

Naphthofluorescein: Mint3 inhibitor with antitumor/anti-inflammatory effect, non-toxic; doubles as pH-sensitive fluorescence probe.

ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.

MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and …

HIF-1 inhibitor-4 (HIF-1 inhibitor-4) is a HIF-1 inhibitor with IC50 of 560 nM.

Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].

HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can …

Acetylarenobufagin is a steroidal hypoxia-inducible factor-1 (HIF-1) modulator.

HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell …

HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and …

Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.

Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.

Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, …

ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).

HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of …

Isoliquiritin apioside, from Glycyrrhizae radix, inhibits MMP9, MAPK, NF-κB, reduces cancer cell invasion, angiogenesis, and …

Glesatinib, an oral tyrosine kinase inhibitor, targets c-Met and VEGFR2 with IC50s of 29 nM …

R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.