Product Information
Name:MMP-3 Inhibitor VIII
Synonyms:
- Stromelysin-1 Inhibitor VIII
- Matrix Metalloproteinase-3 Inhibitor VIII
Brand:Targetmol
Description:Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME/MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:406.5
Formula:C20H26N2O5S
Color/Form:Solid
Technical inquiry about: MMP-3 Inhibitor VIII
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