Product Information
Name:17(R)-Resolvin D1 methyl ester
Synonyms:
- Aspirin-triggered-Resolvin D1 methyl ester
Brand:Targetmol
Description:17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC50= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its pharmacokinetic and distribution properties as a more lipophilic prodrug, can be converted back into the active acid form by intracellular esterases.
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Chemical properties
Molecular weight:390.5
Formula:C23H34O5
Color/Form:Solid
Technical inquiry about: 17(R)-Resolvin D1 methyl ester
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