Product Information
- (5S,6E,8Z,11Z,14Z,17Z)-5-Hydroxy-6,8,11,14,17-eicosapentaenoic acid
- 5-Hepe
- 5-Hydroxyeicosapentaenoic acid
- 6,8,11,14,17-Eicosapentaenoic acid, 5-hydroxy-, (5S,6E,8Z,11Z,14Z,17Z)-
- 6,8,11,14,17-Eicosapentaenoic acid, 5-hydroxy-, [S-(E,Z,Z,Z,Z)]-
- 92008-51-0
5(S)-HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO). This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 µM concentration. Additionally, 5(S)-HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5(S)-HEPE are increased in hyperlipidemia patients.
Chemical properties
Technical inquiry about: TM-T84567 5(S)-HEPE
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