Product Information
- (±)5,6-DiHETrE
- (+/-)5,6-DiHETrE
- (8Z,11Z,14Z)-5,6-Dihydroxy-8,11,14-eicosatrienoic acid
- (±)-5,6-Dihydroxy-8Z,11Z,14Z-eicosatrienoic acid
- 213382-49-1
- 5,6-Dhet
- 5,6-Dihydroxyeicosatrienoic acid
- 8,11,14-Eicosatrienoic acid, 5,6-dihydroxy-, (8Z,11Z,14Z)-
5(6)-DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5(6)-EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5(6)-EET, facilitating its measurement by utilizing the compound's conversion to 5(6)-δ-lactone in solution. Additionally, 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. It also acts as a substrate for sheep seminal vesicle COX, leading to the in vitro production of 5,6-dihydroxy prostaglandin E1 and F1α metabolites. Notably, its levels diminish in the plasma of rats subjected to a high-fat diet, indicating a potential role in the pathophysiology of hyperlipidemia.
Chemical properties
Technical inquiry about: TM-T84609 (±)5(6)-DiHET
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