Product Information
Name:(±)-N-desmethyl Venlafaxine hydrochloride
Synonyms:
- Wy 45494
Brand:Targetmol
Description:(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a minimum effective dose (MED) of 10 mg/kg.
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Chemical properties
Molecular weight:299.836
Formula:C16H26ClNO2
Color/Form:Solid
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