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14S(15R)-EET methyl ester

CAS:

Ref. TM-T85051

14S(15R)-EET methyl ester
Targetmol

Product Information

Name:14S(15R)-EET methyl ester
Brand:Targetmol
Description:14S(15R)-EET methyl ester, an oxylipin derived from arachidonic acid through cytochrome P450 metabolism, demonstrates specific biological activities. It exhibits affinity for isolated guinea pig monocytes, evidenced by a competitive binding assay with a Ki value of 612.5 nM using [3H]14(15)-EET. This compound notably enhances the dilation of precontracted isolated canine epicardial arterioles (EC50= 4 pM) and denuded porcine subepicardial arterioles (EC50= 3 pM), indicating potent vasodilatory effects. Unlike its isomer 14R(15S)-EET, 14S(15R)-EET methyl ester does not inhibit COX activity in enzyme assays or affect isolated platelets, highlighting its distinct functional profile.
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Chemical properties

Molecular weight:334.49
Formula:C21H34O3
Color/Form:Solid

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