Product Information
Name:(±)17(18)-EpETE-Ethanolamide
Synonyms:
- 17,18-epoxy-Eicosatetraenoic Acid Ethanolamide
- 17,18-EEQ-EA
- (±)17,18-EEQ-Ethanolamide
- (±)17(18)-EpETE-EA
Brand:Targetmol
Description:(±)17(18)-EpETE-Ethanolamide, an ω-3 endocannabinoid epoxide, originates from eicosapentaenoic ethanolamide (EPEA) through cytochrome P450 (CYP) epoxygenases action and is decomposed by soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FA, AH). Its endogenous synthesis occurs in LPS-stimulated and EPEA-supplemented BV-2 microglia cells, a process inhibited by the CYP inhibitor ketoconazole. This compound mitigates IL-6 and nitrite levels while enhancing IL-10 production following LPS exposure in BV-2 microglia. At a dose of 50 µM, it prevents platelet aggregation caused by arachidonic acid but not that triggered by ADP, collagen, or ristocetin. Additionally, it facilitates the dilation of constricted bovine coronary arteries (ED50= 1.1 µM) and blocks VEGF-driven tubulogenesis in human microvascular endothelial cells (HMVECs).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:361.52
Formula:C22H35NO3
Color/Form:Solid
Technical inquiry about: (±)17(18)-EpETE-Ethanolamide
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