Product Information
- 3:PN: WO0212307 SEQID: 3 claimed protein
- Human urocortin 2
- Urocortin II(human)
- Urocortin-related peptide (human)
- Stresscopin-Related Peptide (6-43) (Human) Trifluoroacetate Salt
Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) family-which comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin I-displays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arterial blood pressure in both normotensive and spontaneously hypertensive rats through peripheral CRF2 receptor agonism, inducing dose-dependent tachycardia and hypotension at doses of 3 and 30 pmol/kg. Additionally, it mitigates the visceral pain response to colorectal distension at 10 and 20 μg/kg in conscious rats and delays gastric emptying in mice.
Chemical properties
Technical inquiry about: TM-T85181 Urocortin II (human) TFA
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