Product Information
Name:WH244
Brand:Targetmol
Description:WH244 is a second-generation dual degrader (PROTAC) targeting BCL-2 and BCL-xL proteins. It effectively degrades these proteins with high specificity, exhibiting a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2. By promoting ubiquitination and subsequent proteasomal degradation of these proteins, WH244 restores apoptotic pathways in cells. The compound shows strong antitumor activity.
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Chemical properties
Molecular weight:1681.51
Formula:C83H105ClF3N13O11S4
Color/Form:Solid
Technical inquiry about: WH244
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