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CHMFL-48
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CHMFL-48

CAS: 2479290-65-6

Ref. TM-T89947

10mgTo inquire
50mgTo inquire
Estimated delivery in United States, on Friday 14 Feb 2025

Product Information

Name:
CHMFL-48
Description:

CHMFL-48, an orally active inhibitor of BCR-ABL kinase, demonstrates efficacy against both the wild-type (wt) and various imatinib-resistant mutants. It exhibits potent inhibitory activity, with IC 50 values of 1 nM for the ABL wild-type and 0.8 nM for the ABL T315I mutant. CHMFL-48 operates by inhibiting the autophosphorylation of both wild-type and mutant BCR-ABL, affecting downstream signaling mediators including STAT5 and CRKL. This disruption leads to cell cycle arrest and triggers apoptosis. Given its properties, CHMFL-48 is a promising candidate for research on chronic myeloid leukemia (CML).

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Targetmol
Long term storage:
Notes:

Chemical properties

Molecular weight:
573.61
Formula:
C31H30F3N7O
Color/Form:
Liquid
MDL:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Technical inquiry about: TM-T89947 CHMFL-48

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