HM43239
CAS: 2294874-49-8
Ref. TM-T9428
| 1mg | 69.00 € | ||
| 5mg | 150.00 € | ||
| 10mg | 221.00 € | ||
| 25mg | 434.00 € | ||
| 50mg | 620.00 € | ||
| 100mg | 862.00 € | ||
| 1ml*10 (DMSO) | 185.00 € |
Product Information
- HM-43239
HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells [1] [2] [3].
Chemical properties
Technical inquiry about: TM-T9428 HM43239
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