Beclin-1 Protein, Mouse, Recombinant (His & SUMO)
Ref. TM-TMPH-02538
| 1mg | 2,201.00 € | ||
| 20µg | 364.00 € | ||
| 100µg | 670.00 € |
Product Information
- Beclin-1, GT197, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1
Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis including endosome formation in neuronal cells. May play a role in antiviral host defense.; Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.
Chemical properties
Technical inquiry about: TM-TMPH-02538 Beclin-1 Protein, Mouse, Recombinant (His & SUMO)
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