TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)
Ref. TM-TMPJ-00624
| 1mg | 2,062.00 € | ||
| 10µg | 88.00 € | ||
| 50µg | 206.00 € | ||
| 500µg | 1,452.00 € |
Product Information
- Tim3, HAVcr-2, Timd3, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin mucin receptor 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell membrane protein 3
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
Chemical properties
Technical inquiry about: TM-TMPJ-00624 TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)
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