B7-1 Protein, Cynomolgus, Recombinant (hFc)
Ref. TM-TMPJ-00630
| 1mg | 2,372.00 € | ||
| 10µg | 80.00 € | ||
| 50µg | 213.00 € | ||
| 500µg | 1,655.00 € |
Product Information
- B7, CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen
Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
Chemical properties
Technical inquiry about: TM-TMPJ-00630 B7-1 Protein, Cynomolgus, Recombinant (hFc)
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