EDEM2 Protein, Human, Recombinant (His)
Ref. TM-TMPY-03870
| 100µg | 686.00 € |
Product Information
- UNQ573/PRO1135, ER degradation enhancer, mannosidase alpha-like 2, ER degradation enhancer, mannosidase α-like 2, C20orf49, C20orf31, bA4204.1
EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM homologs. The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases). EDEM2 is one of the EDEM homologs. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD.
Chemical properties
Technical inquiry about: TM-TMPY-03870 EDEM2 Protein, Human, Recombinant (His)
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