Product Information
Name:NDI-Lyso
Brand:Targetmol
Description:NDI-Lyso is an anticancer agent targeting lysosomes, functioning through an enzyme-induced self-assembly (EISA) mechanism catalyzed by Cathepsin B. In cancer cell lysosomes, it forms rigid long fibers, promoting lysosomal swelling, lysosomal membrane permeabilization (LMP), and membrane disruption. This leads to non-classical caspase-independent apoptosis (Apoptosis). NDI-Lyso demonstrates significant selective anticancer activity across various cancer cell lines and drug-resistant cancer cells (IC50 approximately 10 μM), while exhibiting low toxicity to normal cells (IC50 > 60 μM).
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:1469.69
Formula:C71H100N22O13
Color/Form:Solid
Technical inquiry about: NDI-Lyso
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