Abacavir-d4

CAS: 1217731-56-0

Ref. TR-A105002

Product Information

• Name: Abacavir-d4
• Synonyms: (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol,(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-methanol, 1592U89-d4, ABC-d4, Abacavir Stable Isotope

Description

Stability Very Hygroscopic
Applications Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

• Brand: TRC

Chemical properties

• Molecular weight: 290.36
• Formula: C₁₄H₁₄D₄N₆O
• Color/Form: Off-White
• InChI: InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1/i2D2,3D2
• InChI key: InChIKey=MCGSCOLBFJQGHM-ZOTQTBSBSA-N
• SMILES: [2H]C1([2H])C(Nc2nc(N)nc3c2ncn3[C@H]2C=C[C@@H](CO)C2)C1([2H])[2H]