Product Information
Name:ent-Abacavir
Controlled Product
Synonyms:
- (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol,(1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
- (1R,4S)-Abacavir
- Abacavir EP Impurity A
- Abacavir Impurities
Brand:TRC
Description:Impurity Abacavir EP Impurity AApplications ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:286.33
Formula:C14H18N6O
Color/Form:Neat
InChI:InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m0/s1
InChI key:InChIKey=MCGSCOLBFJQGHM-WCBMZHEXSA-N
SMILES:Nc1nc(NC2CC2)c2ncn([C@@H]3C=C[C@H](CO)C3)c2n1
Technical inquiry about: ent-Abacavir
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