Product Information
Name:6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine
Controlled Product
Synonyms:
- [6-(4-Aminophenoxy)pyrimidin-4-yl]methylamine
Brand:TRC
Description:Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);
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Chemical properties
Molecular weight:216.239
Formula:C11H12N4O
Color/Form:Neat
InChI:InChI=1S/C11H12N4O/c1-13-10-6-11(15-7-14-10)16-9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
InChI key:InChIKey=RZDFAPUGWUDWPR-UHFFFAOYSA-N
SMILES:CNc1cc(Oc2ccc(N)cc2)ncn1
Technical inquiry about: 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine
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