(3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester

CAS: 1168152-06-4

Ref. TR-A173865

Product Information

• Name: (3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester
• Synonyms: 1H-Indole-6-carboxylic acid, 1-acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-, methyl ester, (3E)- (ACI), Methyl (3E)-1-acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylate (ACI)
• Brand: TRC
• Description: Applications (3E)-1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic Acid Methyl Ester is an impurity of Intedanib (I666650), an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases.References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Chemical properties

• Molecular weight: 365.379
• Formula: C₂₁H₁₉NO₅
• Color/Form: Neat
• InChI: InChI=1S/C21H19NO5/c1-4-27-19(14-8-6-5-7-9-14)18-16-11-10-15(21(25)26-3)12-17(16)22(13(2)23)20(18)24/h5-12H,4H2,1-3H3/b19-18+
• InChI key: InChIKey=GIIOASILGOFVPI-UHFFFAOYSA-N
• SMILES: CC(Cc1ccc(O)c(O)c1)C(=O)O