Product Information
Name:Ac-LEHD-AFC Trifluoroacetic Acid Salt
Controlled Product
Synonyms:
- Ac-LEHD-AFC (trifluoroacetate salt)
- -α-Asparagine
- N-acetyl-L-leucyl-L-α-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
- compd. with 2,2,2-trifluoroacetic acid
Brand:TRC
Description:Applications Ac-LEHD-AFC Trifluoroacetic Acid Salt is a fluorogenic substrate that is cleaved by caspases (4,5 and 9). This activity is quantified by fluorescent detection of free AFC. Caspase-9 activation is critical for intrinsic cell death.References Yin, Q. et al.: Mol. Cell., 22, 259 (2006); Kyewhan, P. et al.: Biochem. Biophys. Res. Comm., 347, 941 (2006);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:765.69 + x(114.02)
Formula:C33H38F3N7O11·x(C2HF3O2)
Color/Form:Neat
InChI:InChI=1S/C33H38F3N7O11.C2HF3O2/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17;3-2(4,5)1(6)7/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,45,46)(H,47,48);(H,6,7)/t21-,22-,23-,24-;/m0./s1
InChI key:InChIKey=WUAXWQRULBZETB-UHFFFAOYSA-N
SMILES:COc1ccc(CC(=O)O)cc1OC
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