Adefovir Dipivoxil

CAS: 142340-99-6

Ref. TR-A280465

Product Information

• Name: Adefovir Dipivoxil
• Synonyms: 1,1'-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] 2,2-dimethyl-Propanoic acid ester, Propanoic acid, 2,2-dimethyl-, [[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene) ester (9CI), GS 0840, Hepsera, Preveon, bis(POM)-PMEA, 3-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-8,8-dimethyl-3-oxido-7-oxo-2,4,6-trioxa-3lambda~5~-phosphanon-1-yl 2,2-dimethylpropanoate, 9-[2-[Bis[(Pivaloyloxy)Methoxy]Phosphinyl]Methoxy]Ethyl]Adenine, Adefovir Dipivoxl, Adefovir Pivoxil, Adefovir dipivoxil, Gs 0840, Propanoic acid, 2,2-dimethyl-, 1,1′-[[[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene)] ester, Propanoic acid, 2,2-dimethyl-, [[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]phosphinylidene]bis(oxymethylene) ester, [2-(6-Aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate

Description

Applications A nucleotide analog, useful as an oral reverse transcriptase inhibitor (ntRTI).
References Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009), Fourches, D., et al.: Chem. Res. Toxicol., 23, 171 (2010), Ming, X., et al.: Biochem. Pharmacol., 79, 455 (2010),

• Brand: TRC

Chemical properties

• Molecular weight: 501.47
• Formula: C₂₀H₃₂N₅O₈P
• Color/Form: Neat
• InChI: InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
• InChI key: InChIKey=NVGKDZJIFAPATO-UHFFFAOYSA-N