Afatinib N-Oxide
Ref. TR-A355330
25mg
2,090.00€
Product Information
Name:Afatinib N-Oxide
Controlled Product
Synonyms:
- (S,E)-4-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine Oxide
Brand:TRC
Description:Applications Afatinib N-Oxide is a derivative of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.References Ham, J. et al.: Cancer Cell., 29, 159 (2016);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:501.94
Formula:C24H25ClFN5O4
Color/Form:White Solid
InChI:InChI=1S/C24H25ClFN5O4/c1-31(2,33)9-3-5-22(32)30-20-12-16-19(13-21(20)35-23-6-4-10-34-23)27-14-28-24(16)29-15-7-8-18(26)17(25)11-15/h3,5,7-8,11-14,23H,4,6,9-10H2,1-2H3,(H,30,32)(H,27,28,29)/b5-3+/t23-/m0/s1
InChI key:InChIKey=RBTQPKGVXALRKI-CCZWLNLGSA-N
SMILES:C[N+](C)([O-])C/C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCCO1
Technical inquiry about: Afatinib N-Oxide
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