AG-490

CAS: 134036-52-5

Ref. TR-A425000

Product Information

• Name: AG-490
• Synonyms: (Z)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide, (E)-2-Cyano-3-(3,4-Dihydrophenyl)-N-(Phenylmethyl)-2-Propenamide, A-Cyano-(3,4-Dihydroxy)-N-Benzylcinnamamide, A-Cyano-(3,4-Dihydroxy)-N-Benzylcinnamide, 2-Cyano-3-[3,4-Dihydroxyphenyl]-N-[Phenylmethyl]-2-Propenamide, N-Benzyl-3,4-Dihydroxy-Alpha-Cyanocinnamide, Ag490, Tyrphostin AG-490, Tyrphostin B42, (2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

Description

Applications A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stock, J., et al.: J. Biol. Chem., 267, 19753 (1992), Levitzki, A., et al.: Science, 267, 1782 (1995), Meydan., N., et al.: Nature, 379, 645 (1996), Lu, H., et al.: Drug Metab. Dispos., 31, 572 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 294.30
• Formula: C₁₇H₁₄N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8-
• InChI key: InChIKey=QODSJTSVGJXVKI-FMIVXFBMSA-N
• SMILES: N#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCc1ccccc1