Product Information
Name:Agmatine Sulfate
Synonyms:
- Guanidine
- (4-aminobutyl)-
- sulfate (1:1) (8CI
- 9CI)
- 1-(4-Aminobutyl)guanidine sulfate
- NIH 11035
Brand:TRC
Description:Applications General Uses: Neuroprotective, CNS studies, Autism and depression researchDescription:Agmatine Sulfate is a polyamine derived from L-arginine (A769500) decarboxylation and is a known putative endogenous neurotransmitter at imidazoline receptors. Agmatine sulfate displaces clonidine at α2-adrenergic and at imidazoline receptors and was recently shown to exert some neuroprotective effects. It blocks NMDA-receptor associated cation channels. Acts as a competitive inhibitor of nitric oxide synthase (NOS). It functions as neurotransmitter since it is stored in synaptic vesicles and is related from axon terminals by depolarization(1). Protects autistic behavior in rats (2) and reverses depressive like behavior in mice. (3)References Reis DJ, et al. 2000; Trends Pharmacol Sci. 2000 May;21(5):187-93 Kim JW, et al. 2016 Neuropharmacology. Sep 14;113(Pt A):71-81Neis VB, et al. 2016 Pharmacol Biochem Behav. Oct 12;150-151:108-114
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:228.27
Formula:C5H14N4·H2O4S
Color/Form:Neat
InChI:InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
InChI key:InChIKey=PTAYFGHRDOMJGC-UHFFFAOYSA-N
SMILES:N=C(N)NCCCCN.O=S(=O)(O)O
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