Aglepristone

CAS: 124478-60-0

Ref. TR-A430055

Product Information

• Name: Aglepristone
• Synonyms: 11beta-[p-(Dimethylamino)phenyl]-17beta-hydroxy-17-[(Z)-propenyl]estra-4,9-dien-3-one, (11beta,17beta)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propen-1-ylestra-4,9-dien-3-one, [11beta,17beta,17(Z)]-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propenyl)-estra-4,9-dien-3-one, Alizine, RU 534, (11beta,17alpha)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-prop-1-en-1-yl]estra-4,9-dien-3-one, (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propen-1-ylestra-4,9-dien-3-one, 11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-[(Z)-propenyl]estra-4,9-dien-3-one, Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propenyl)-, [11β,17β,17(Z)]-, Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propen-1-yl-, (11β,17β)-, Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propenyl-, (11β,17β)-, Ru 534, estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-1-propen-1-yl]-, (11beta,17alpha)-

Description

Applications Aglepristone is used as a treatment to induce parturition in ewes and their newborns. A competitive progesterone antagonist for treatment of various progesterone-dependent physiology and pathology conditions, and effective means of terminating pregnancy in most species. Also, it prevents sperm progression toward the oviducts and fertilization in inseminated females.
References Ozalp, R. G., et al.: Theriogenology, 87, 141-147 (2017); Gogny, A., et al.: Theriogenology, 85, 555-566 (2016); Reynaud, K., et al.: Biol. Reprod., 93, 1-9 (2015)

• Brand: TRC

Chemical properties

• Molecular weight: 431.61
• Formula: C₂₉H₃₇NO₂
• Color/Form: Neat
• InChI: InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1
• InChI key: InChIKey=RTCKAOKDXNYXEH-FWSJOHTJSA-N
• SMILES: C/C=C\[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(N(C)C)cc3)C[C@@]21C