(aS)-a-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine Methyl Ester Mono(trifluoroacetate)

CAS: 868539-99-5

Ref. TR-A591425

Product Information

• Name: (aS)-a-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine Methyl Ester Mono(trifluoroacetate)
• Synonyms: (αS)-α-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine Methyl Ester 2,2,2-Trifluoroacetate
• Brand: TRC
• Description: Applications (αS)-α-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine Methyl Ester Mono(trifluoroacetate) is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.References Smyth, M., et al.: Compounds for proteasome enzyme inhibition, US Patent 20090131421, May 21, 2009

Chemical properties

• Molecular weight: 567.6
• Formula: C₂₈H₃₆F₃N₃O₆
• Color/Form: Neat
• InChI: InChI=1S/C26H35N3O4.C2HF3O2/c1-18(2)16-22(28-24(30)21(27)15-14-19-10-6-4-7-11-19)25(31)29-23(26(32)33-3)17-20-12-8-5-9-13-20;3-2(4,5)1(6)7/h4-13,18,21-23H,14-17,27H2,1-3H3,(H,28,30)(H,29,31);(H,6,7)/t21-,22-,23-;/m0./s1
• InChI key: InChIKey=LAPJYAIMBWUZSL-RZQZFQKJSA-N
• SMILES: COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)C(N)CCc1ccccc1.O=C(O)C(F)(F)F