Product Information
Name:N-des-succinyl-Sacubitril hydrochloride
Controlled Product
Synonyms:
- [S-(R*,S*)]-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride
- Ethyl (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride,(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
- (αR,γS)-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride
Brand:TRC
Description:Applications (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.References Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015; Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:384.34
Formula:C20H25NO2·HCl
Color/Form:Neat
InChI:InChI=1S/C20H25NO2.ClH/c1-3-23-20(22)15(2)13-19(21)14-16-9-11-18(12-10-16)17-7-5-4-6-8-17;/h4-12,15,19H,3,13-14,21H2,1-2H3;1H/t15-,19+;/m1./s1
InChI key:InChIKey=OKDSPZRSANXDRL-BEFAXECRSA-N
SMILES:CCOC(=O)[C@H](C)C[C@H](N)Cc1ccc(-c2ccccc2)cc1.Cl
Technical inquiry about: N-des-succinyl-Sacubitril hydrochloride
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