N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester

CAS: 1013330-79-4

Ref. TR-A601630

Product Information

• Name: N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester
• Synonyms: methyl N-[[4-[(2-amino-5-phenylphenyl)carbamoyl]phenyl]methyl]carbamate
• Brand: TRC

Description

Applications N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester is a biaryl benzamides that exhibit inhibitory selectivity over class II Histone Deacetylase (HDACs) and as well as class I HDACs. N-[[4-[[(4-Amino[1,1'-biphenyl]-3-yl)amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester was deteremined to be a potent and selective inhibitor of HDAC with reduced off-target activity and tumor growth inhibition activity.
References Witter, D.J., et al.: Bioorg. Medn. Chem. Letters., 18, 726 (2008);

Chemical properties

• Molecular weight: 375.42
• Formula: C₂₂H₂₁N₃O₃
• Color/Form: Neat
• InChI: InChI=1S/C22H21N3O3/c1-28-22(27)24-14-15-7-9-17(10-8-15)21(26)25-20-13-18(11-12-19(20)23)16-5-3-2-4-6-16/h2-13H,14,23H2,1H3,(H,24,27)(H,25,26)
• InChI key: InChIKey=QLRRIESOGZTMDR-UHFFFAOYSA-N
• SMILES: COC(=O)NCc1ccc(C(=O)Nc2cc(-c3ccccc3)ccc2N)cc1