Product Information
Name:2-Amino-5-chlorobenzenesulfonamide
Controlled Product
Synonyms:
- Hydrochlorothiazide Impurity 28
Brand:TRC
Description:Applications 2-Amino-5-chlorobenzenesulfonamide is a metabolite of IDRA-21 (I232500), which inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).References Cannazza, G., et. al.: Bioorg. Med. Chem. Lett., 19, 1254 (2009); Zivkovic, et al.: J. Pharmacol. Exp. Ther., 272, 300 (1995); Dingledine, R., et al.: Pharmacol. Rev., 51, 7 (1999); Sun, Y., et al.: Nature, 417, 245 (2002); Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006)
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Chemical properties
Molecular weight:206.65
Formula:C6H7ClN2O2S
Color/Form:Neat
InChI:InChI=1S/C6H7ClN2O2S/c7-4-1-2-5(8)6(3-4)12(9,10)11/h1-3H,8H2,(H2,9,10,11)
InChI key:InChIKey=RBCLOSOKWLMKMB-UHFFFAOYSA-N
SMILES:Nc1ccc(Cl)cc1S(N)(=O)=O
Technical inquiry about: 2-Amino-5-chlorobenzenesulfonamide
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