2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide

CAS: 849668-91-3

Ref. TR-A605055

Product Information

• Name: 2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide
• Synonyms: 2-Amino-N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-4,5-dimethoxybenzamide
• Brand: TRC

Description

Applications 2-Amino-N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-4,5-dimethoxybenzamide is an intermediate in the synthesis of Tariquidar (T007600), a P-glycoprotein drug efflux pump inhibitor that is potentially used in cancer patients.
References Fox. E., et al.: Expert. Rev. Anticancer. Ther., 7, 447 (2007); Hernandez, D., et al.: Biochem. Pharmacol., 85, 21 (2013); Bauer, F., et al.: Euro. J. Pharmacol., 696, 18 (2012);

Chemical properties

• Molecular weight: 491.58
• Formula: C₂₈H₃₃N₃O₅
• Color/Form: Neat
• InChI: InChI=1S/C28H33N3O5/c1-33-24-13-19-10-12-31(17-20(19)14-25(24)34-2)11-9-18-5-7-21(8-6-18)30-28(32)22-15-26(35-3)27(36-4)16-23(22)29/h5-8,13-16H,9-12,17,29H2,1-4H3,(H,30,32)
• InChI key: InChIKey=QQZQREKTYHZVCS-UHFFFAOYSA-N
• SMILES: COc1cc(N)c(C(=O)Nc2ccc(CCN3CCc4cc(OC)c(OC)cc4C3)cc2)cc1OC