(2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate

CAS: 247068-85-5

Ref. TR-A612145

Product Information

• Name: (2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate
• Synonyms: (2S)-2-Amino-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-pentanone 2,2,2-Trifluoroacetate
• Brand: TRC

Description

Applications (2S)-2-Amino-4-methyl-1-[(2R)-2-methyloxiranyl]-1-pentanone Trifluoroacetate is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Xiao, Q., et al.: Process for preparation of carfilzomib, China Patent 104710507, Jun 17, 2015; Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012)

Chemical properties

• Molecular weight: 285.26
• Formula: C₉H₁₇NO₂·C₂HF₃O₂
• Color/Form: Neat
• InChI: InChI=1S/C9H17NO2.C2HF3O2/c1-6(2)4-7(10)8(11)9(3)5-12-9;3-2(4,5)1(6)7/h6-7H,4-5,10H2,1-3H3;(H,6,7)/t7-,9+;/m0./s1
• InChI key: InChIKey=OWGGQBZQMQMPBI-LJGVWRNTSA-N
• SMILES: CC(C)CC(N)C(=O)[C@@]1(C)CO1.O=C(O)C(F)(F)F