N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine

CAS: 376633-24-8

Ref. TR-A612560

Product Information

• Name: N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine
• Synonyms: GS 7160, Tenofovir Impurity

Description

Applications N-[[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]hydroxyphosphinyl]-D-alanine is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. It is used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007);

• Brand: TRC

Chemical properties

• Molecular weight: 358.29
• Formula: C₁₂H₁₉N₆O₅P
• Color/Form: Neat
• InChI: InChI=1S/C12H19N6O5P/c1-7(23-6-24(21,22)17-8(2)12(19)20)3-18-5-16-9-10(13)14-4-15-11(9)18/h4-5,7-8H,3,6H2,1-2H3,(H,19,20)(H2,13,14,15)(H2,17,21,22)/t7-,8-/m1/s1
• InChI key: InChIKey=VNZDKODEBZWTMP-HTQZYQBOSA-N
• SMILES: C[C@H](Cn1cnc2c(N)ncnc21)OCP(=O)(O)N[C@H](C)C(=O)O