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1-(4-Aminophenyl)cyclopentanecarbonitrile-d8
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1-(4-Aminophenyl)cyclopentanecarbonitrile-d8

CAS: 115279-73-7

Ref. TR-A615552

250mg
1,597.00 €
Estimated delivery in United States, on Tuesday 7 Jan 2025

Product Information

Name:
1-(4-Aminophenyl)cyclopentanecarbonitrile-d8
Controlled Product
Synonyms:
  • 1-(4-aminophenyl)-2,2,3,3,4,4,5,5-octadeuteriocyclopentane-1-carbonitrile
  • Cyclopentanecarbonitrile, 1-(4-aminophenyl)-
  • 1-(4-aminophenyl)-Cyclopentanecarbonitrile
  • 1-(4-aminophenyl)cyclopentane-1-carbonitrile
Description:

Applications 1-(4-Aminophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is a labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
194.302
Formula:
C12D8H6N2
Color/Form:
Neat
InChI:
InChI=1S/C12H14N2/c13-9-12(7-1-2-8-12)10-3-5-11(14)6-4-10/h3-6H,1-2,7-8,14H2/i1D2,2D2,7D2,8D2
SMILES:
[2H]C1([2H])C([2H])([2H])C([2H])([2H])C(C#N)(c2ccc(N)cc2)C1([2H])[2H]
MDL:
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Hazard Info

UN Number:
EQ:
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Forbidden to fly:
Hazard Info:
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LQ:

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