Product Information
Name:Amino Hydroxynimesulide NAC Adduct
Controlled Product
Synonyms:
- N-Acetyl-S-[2-amino-4-(4-hydroxyphenoxy)-5-[(methylsulfonyl)amino]phenyl]-L-cysteine
Brand:TRC
Description:
Applications Amino Hydroxynimesulide is an analog of Nimesulide (N477500), an antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production.
References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998); Li, F. et al.: Chem. Res. Toxicol., 22, 72 (2009);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:455.51
Formula:C18H21N3O7S2
Color/Form:Neat
InChI:InChI=1S/C18H21N3O7S2/c1-10(22)20-15(18(24)25)9-29-17-8-14(21-30(2,26)27)16(7-13(17)19)28-12-5-3-11(23)4-6-12/h3-8,15,21,23H,9,19H2,1-2H3,(H,20,22)(H,24,25)/t15-/m0/s1
InChI key:InChIKey=LAPPXTHNOPTGSG-HNNXBMFYSA-N
SMILES:CC(=O)N[C@@H](CSc1cc(NS(C)(=O)=O)c(Oc2ccc(O)cc2)cc1N)C(=O)O
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