1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine

CAS: 138564-61-1

Ref. TR-A622450

Product Information

• Name: 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine
• Synonyms: [2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl](4-methyl-1-piperazinyl)methanone, 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methylpiperazine (9CI)
• Brand: TRC

Description

Applications 1-[[2-[(2-Aminophenyl)amino]-5-methyl-3-thienyl]carbonyl]-4-methyl-piperazine is an impurity of Olanzapine (O253750), a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity.
References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)

Chemical properties

• Molecular weight: 330.45
• Formula: C₁₇H₂₂N₄OS
• Color/Form: Neat
• InChI: InChI=1S/C17H22N4OS/c1-12-11-13(17(22)21-9-7-20(2)8-10-21)16(23-12)19-15-6-4-3-5-14(15)18/h3-6,11,19H,7-10,18H2,1-2H3
• InChI key: InChIKey=NVVVXCDSGMPBCB-UHFFFAOYSA-N
• SMILES: Cc1cc(C(=O)N2CCN(C)CC2)c(Nc2ccccc2N)s1