Aminopterin

CAS: 54-62-6

Ref. TR-A628850

Product Information

• Name: Aminopterin
• Synonyms: L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-, L- (8CI), N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, APGA, Aminopterine, NSC 739, Pteramina, (S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid, Methotrexate Imp. B (EP)
• Brand: TRC
• Description: Impurity Methotrexate EP Impurity BApplications Aminopterin (Methotrexate EP Impurity B) is a folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inhibits its activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985), Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1990), Roy, K., et al.: J. Biol. Chem., 273, 2526 (1998),

Chemical properties

• Molecular weight: 440.41
• Formula: C₁₉H₂₀N₈O₅
• Color/Form: Yellow
• InChI: InChI=1S/C19H20N8O5/c20-15-14-16(27-19(21)26-15)23-8-11(24-14)7-22-10-3-1-9(2-4-10)17(30)25-12(18(31)32)5-6-13(28)29/h1-4,8,12,22H,5-7H2,(H,25,30)(H,28,29)(H,31,32)(H4,20,21,23,26,27)/t12-/m0/s1
• InChI key: InChIKey=TVZGACDUOSZQKY-LBPRGKRZSA-N
• SMILES: Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1