3(4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one

CAS: 36725-28-7

Ref. TR-A628920

Product Information

• Name: 3(4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
• Synonyms: 6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone, 6-(p-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, SKF 93505
• Brand: TRC

Description

Applications AMDP3 (4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one) acts as a cardiac troponin effecter, resulting in activation of cardiac muscle contractions. It’s an analogue to Levosimendan (L378000), positive inotropic agent with vasodilating activity.
References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996); Robertson, I. et al.: Biochem., 47, 7485 (2008);

Chemical properties

• Molecular weight: 203.24
• Formula: C₁₁H₁₃N₃O
• Color/Form: Neat
• InChI: InChI=1S/C11H13N3O/c1-7-6-10(15)13-14-11(7)8-2-4-9(12)5-3-8/h2-5,7H,6,12H2,1H3,(H,13,15)
• InChI key: InChIKey=GDMRFHZLKNYRRO-UHFFFAOYSA-N
• SMILES: CC1CC(=O)NN=C1c1ccc(N)cc1