4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

CAS: 91366-65-3

Ref. TR-A629400

Product Information

• Name: 4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole
• Synonyms: 7-fluoro-2,1,3-benzoxadiazole-4-sulfonamide, 7-Fluoro-2,1,3-Benzoxadiazole-4-Sulfonamide, 4-Fluoro-7-sulfamoylbenzofurazan, 7-Fluorobenzo[c][1,2,5]oxadiazole-4-sulfonamide

Description

Applications A water soluble pH dependent bifunctional fluorogenic reagent for the sensitive and specific detection of protein thiols. ABD-F is highly reactive and specific for protein thiols, and its selectivity is superior to that of other sulfhydryl-reactive fluorophores such as fluorescein maleimide, 5-iodoacetamidofluorescein, 5-I-AEDANS, dansylaziridine, and bimane. Fluorescence: max Abs. l = 385nm, max Em. l = 520nm; Molar Abs. >4.5x103 (ca. 315nm)
References Hiratsuka., T.,: J. Biol. Chem., 268, 24742 (1993), Treuheit, M.J., et al.: Anal. Biochem., 212, 138 (1993), Takeda., S., et al.: Trans. Mater. Res. Soc. Jpn., 15A, 509 (1994), Tukushima, T., et al.: Biomed. Chromatogr., 9, 10 (1995), Takeda., S., et al.: J. Biochem., 117, 267 (1995)

• Brand: TRC

Chemical properties

• Molecular weight: 217.18
• Formula: C₆H₄FN₃O₃S
• Color/Form: Neat
• InChI: InChI=1S/C6H4FN3O3S/c7-3-1-2-4(14(8,11)12)6-5(3)9-13-10-6/h1-2H,(H2,8,11,12)
• InChI key: InChIKey=XROXHZMRDABMHS-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)c1ccc(F)c2nonc12