9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate

CAS: 1684-40-8

Ref. TR-A629700

Product Information

• Name: 9-Amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate
• Synonyms: 9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride (1:1), 9-Acridinamine, 1,2,3,4-tetrahydro-, monohydrochloride (9CI), Acridine, 9-amino-1,2,3,4-tetrahydro-, hydrochloride (7CI), Acridine, 9-amino-1,2,3,4-tetrahydro-, monohydrochloride (8CI), 1,2,3,4-Tetrahydro-9-aminoacridine hydrochloride, 5,6,7,8-Tetrahydroacridin-9-amine hydrochloride, 9-Amino-1,2,3,4-Tetrahydroacridine hydrochloride, CI 970, Cognex, Hydroaminacrine, Romotal, THA, Tacrin hydrochloride, Tacrine hydrochloride
• Brand: TRC

Description

Applications A potent centrally acting anticholinesterase, for therapy of memory deficits in patients with Alzheimers's disease. THA also selectively blocks potassium channels in the central nervous system, which results in an increased release of acetylcholine and a prolongation of the action potential of the presynaptic cholinergic neurons.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Harper, J., et al.: Chem. Biol., 4, 119 ( 1997), Kirkitadze, M., et al.: J. Mol. Biol., 312, 1103 (2001), Zhuang, Z., et al.: J. Med. Chem., 44, 1905 (2001), Necula, M.J., et al.: Biol. Chem., 282, 10311 (2007),

Chemical properties

• Molecular weight: 234.72
• Formula: C₁₃H₁₄N₂·ClH
• Color/Form: Neat
• InChI: InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
• InChI key: InChIKey=ZUFVXZVXEJHHBN-UHFFFAOYSA-N
• SMILES: Cl.Nc1c2c(nc3ccccc13)CCCC2