9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate

CAS: 118909-22-1

Ref. TR-A629900

Product Information

• Name: 9-Amino-1,2,3,4-tetrahydroacridin-1-ol Maleate
• Synonyms: 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (2Z)-2-butenedioate (1:1) (ACI), 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (2Z)-2-butenedioate (1:1) (salt) (9CI), 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (±)-, (Z)-2-butenedioate (1:1) (salt) (ZCI), 1-Acridinol, 9-amino-1,2,3,4-tetrahydro-, (Z)-2-butenedioate (1:1) (salt), HP 029, Mentane, P 83-6029A, Velnacrine hydrogen maleate, Velnacrine maleate
• Brand: TRC

Description

Applications A potential Alzheimer's Disease therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to THA except that it is far less toxic and without measurable liver toxicity in humans.
References Alon, R., et al.: J. Cell Biol., 128, 1243 (1995), Min, W., et al.: J .Immunol., 159, 3508 (1997), Lum, A., et al.: J. Biol. Chem., 277, 20660 (2002), Carvalho, F., et al.: J. Appl. Toxicol., 24, 419 (2004),

Chemical properties

• Molecular weight: 330.34
• Formula: C₁₃H₁₄N₂O·C₄H₄O₄
• Color/Form: Neat
• InChI: InChI=1S/C13H14N2O.C4H4O4/c14-13-8-4-1-2-5-9(8)15-10-6-3-7-11(16)12(10)13;5-3(6)1-2-4(7)8/h1-2,4-5,11,16H,3,6-7H2,(H2,14,15);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: InChIKey=NEEKVKZFYBQFGT-BTJKTKAUSA-N
• SMILES: Nc1c2c(nc3ccccc13)CCCC2O.O=C(O)/C=C\C(=O)O