Anastrozole EP Impurity E (2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)

CAS: 120511-88-8

Ref. TR-A637428

Product Information

• Name: Anastrozole EP Impurity E (2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile)
• Synonyms: 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile, 2,2'-[5-(Hydroxymethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile), Anastrozole Imp. E (EP),5-(Hydroxymethyl)-α1,α1,α3,α3-tetramethyl-1,3-benzenediacetonitrile, 1,3-Benzenediacetonitrile, 5-(hydroxymethyl)-α,α,α',α'-tetramethyl- (9CI)
• Brand: TRC
• Description: Impurity Anastrozole EP Impurity EApplications 2-[3-(Cyanodimethylmethyl)-5-hydroxymethylphenyl]-2-methylpropionitrile (Anastrozole EP Impurity E ) is an impurity of Anastrozole (A637425), an aromatase inhibitor which functions as an antineoplastic (1,2). Anastrozole is used in post-menopausal women with advanced breast cancer.References 1. Plourde, P. et al.: Breast Cancer Res Treat. 1994;30(1):103-112. Buzdar, A. et al.: Cancer. 1997 Feb 15;79(4):730-9.

Chemical properties

• Molecular weight: 242.32
• Formula: C₁₅H₁₈N₂O
• Color/Form: Neat
• InChI: InChI=1S/C15H18N2O/c1-14(2,9-16)12-5-11(8-18)6-13(7-12)15(3,4)10-17/h5-7,18H,8H2,1-4H3
• SMILES: CC(C)(C#N)c1cc(CO)cc(C(C)(C)C#N)c1