Arimoclomol

CAS: 289893-25-0

Ref. TR-A771278

Product Information

• Name: Arimoclomol
• Synonyms: (R)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide, Arimoclomol [INN], Arimoclomolum, Arimoclomolum [INN-Latin], Brx 345, N-((2R)-2-Hydroxy-3-(1-piperidyl)propoxy)pyridine-3-carboximidoyl chloride, 1-oxide, Unii-Eut3557Rt5, 3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide, N-{[(2R)-2-hydroxy-3-(piperidin-1-yl)propyl]oxy}pyridine-3-carboximidoyl chloride 1-oxide
• CAS: 289893-25-0

Description

Stability Hygroscopic
Applications Arimoclomol is a co-inducer of HSP that acts through heat shock factor 1 (HSF1) in cells undergoing cellular stress. Has therapeutic potential in motor neuron degenerative diseases. Potential treatment for liposomal storage disorders, such as Niemann-Pick disease type C.
References Kieran, Dairin., et al.: Nature Medicine., 10, 402 (2004); Brown, Ian R., et al.: Ann N Y Acad Sci., 1113, 147 (2007); Traynor, B. J., et al.: Neurology., 67, 20 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 313.78
• Formula: C₁₄H₂₀ClN₃O₃
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/b16-14-/t13-/m1/s1
• InChI key: InChIKey=SGEIEGAXKLMUIZ-XUVDNFPMSA-N
• SMILES: [O-][n+]1cccc(/C(Cl)=N/OC[C@H](O)CN2CCCCC2)c1