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CAS 289893-25-0

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Arimoclomol

Description:
Arimoclomol is a chemical compound classified as a small molecule and is primarily known for its role as a pharmacological agent. It functions as a co-inducer of heat shock proteins, which are crucial for cellular protection and stress response. Arimoclomol has been investigated for its potential therapeutic applications in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Huntington's disease, due to its ability to enhance cellular resilience against stressors. The compound exhibits a favorable safety profile in clinical studies, and its mechanism of action involves the modulation of protein folding and degradation pathways, thereby promoting cell survival under adverse conditions. Additionally, arimoclomol is characterized by its solubility in organic solvents and moderate stability under physiological conditions. Its development highlights the importance of heat shock protein modulation in treating diseases characterized by protein misfolding and aggregation. Overall, arimoclomol represents a promising avenue in the field of neuroprotection and therapeutic strategies for neurodegenerative disorders.
Formula:C14H20ClN3O3
InChI:InChI=1S/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/t13-/m1/s1
InChI key:InChIKey=SGEIEGAXKLMUIZ-CYBMUJFWSA-N
SMILES:C(=NOC[C@@H](CN1CCCCC1)O)(Cl)C2=CN(=O)=CC=C2
Synonyms:
  • Arimoclomol [INN]
  • Arimoclomol
  • Arimoclomolum
  • Arimoclomolum [INN-Latin]
  • Brx 345
  • N-((2R)-2-Hydroxy-3-(1-piperidyl)propoxy)pyridine-3-carboximidoyl chloride, 1-oxide
  • Unii-Eut3557Rt5
  • 3-Pyridinecarboximidoyl chloride, N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-, 1-oxide
  • N-{[(2R)-2-hydroxy-3-(piperidin-1-yl)propyl]oxy}pyridine-3-carboximidoyl chloride 1-oxide
  • BRX 345 free base
Found 6 products.