Astemizole

CAS: 68844-77-9

Ref. TR-A790030

Product Information

• Name: Astemizole
• Synonyms: 1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine, Astemisan, Hismanal, Histamen, Paralergin, R 42512, R 43512, Retolen, Waruzol, 1-((4-fluorophenyl)-methyl)-N-(1-(2-(4-methoxyphenyl)ethyl)-4-piperidinyl)-1H-benzimidazol-2-amine, 1-(4-Fluorobenzyl)-2-(1-(4-methoxyphenethyl)piperidin-4-yl)aminobenzimidazole, 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, 1H-Benzimidazol-2-amine, 1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-, Astemizol, Histaminos, Histazol, Kelp, Laridal, Metodik, Novo-Nastizol A, Nsc 329963, Stemiz
• CAS: 68844-77-9

Description

Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.
References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),

• Brand: TRC

Chemical properties

• Molecular weight: 458.57
• Formula: C₂₈H₃₁FN₄O
• Color/Form: White To Off-White
• InChI: InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
• InChI key: InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N
• SMILES: COc1ccc(CCN2CCC(N=c3[nH]c4ccccc4n3Cc3ccc(F)cc3)CC2)cc1