N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-Naphthalenecarboxamide

CAS: 1227162-75-5

Ref. TR-A795305

Product Information

• Name: N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-Naphthalenecarboxamide
• Synonyms: 1-Naphthalenecarboxamide, N-(3S)-1-azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-, (S)-N-(Quinuclidin-3-yl)-5,6-dihydronaphthalene-1-carboxamide
• Brand: TRC
• Description: Applications N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-5,6-dihydro-1-Naphthalenecarboxamide is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

Chemical properties

• Molecular weight: 282.38
• Formula: C₁₈H₂₂N₂O
• Color/Form: Neat
• InChI: InChI=1S/C18H22N2O/c21-18(19-17-12-20-10-8-14(17)9-11-20)16-7-3-5-13-4-1-2-6-15(13)16/h2-3,5-7,14,17H,1,4,8-12H2,(H,19,21)/t17-/m1/s1
• InChI key: InChIKey=JRYSITMMKDCXIF-QGZVFWFLSA-N
• SMILES: O=C(N[C@@H]1CN2CCC1CC2)c1cccc2c1C=CCC2