(2S,5R)-3-(Azidomethyl)-3-methyl-7-oxo-4,4-dioxide-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Diphenylmethyl Ester

CAS: 115546-69-5 89051-49-0

Ref. TR-A824955

Product Information

• Name: (2S,5R)-3-(Azidomethyl)-3-methyl-7-oxo-4,4-dioxide-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Diphenylmethyl Ester
• Synonyms: [(3S,6S)-4,5-dibenzoyloxy-6-[(2S,5R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-methyl-2-oxochromen-7-yl)oxyoxan-3-yl]oxy-2-methyloxan-3-yl] benzoate

Description

Applications (2S,5R)-3-(Azidomethyl)-3-methyl-7-oxo-4,4-dioxide-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid Diphenylmethyl Ester is an intermediate in the synthesis of Tazobactam Sodium Salt-13C2,15N1 (T010102), which is the labelled analogue of Tazobactam Sodium Salt (T010100), which is a β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect.
References Gould, I.M., et al.: Drugs Exp. Clin. Res., 17, 187 (1991), Roland, R.K., et al.: J. Infect. Dis., 4, 226 (2000), Bonomo, R.A., et al.: Biochim. Biophys. Acta, 1547, 196 (2001),

• Brand: TRC

Chemical properties

• Molecular weight: 796.769
• Formula: C₄₃H₄₀O₁₅
• Color/Form: White
• InChI: InChI=1S/C43H40O15/c1-23-20-32(45)53-30-21-28(18-19-29(23)30)52-42-36(34(47)33(46)31(22-44)54-42)58-43-38(57-41(50)27-16-10-5-11-17-27)37(56-40(49)26-14-8-4-9-15-26)35(24(2)51-43)55-39(48)25-12-6-3-7-13-25/h3-21,24,31,33-38,42-44,46-47H,22H2,1-2H3/t24?,31?,33-,34?,35-,36?,37?,38?,42+,43-/m0/s1
• InChI key: InChIKey=KLLPZKHKRGTNCW-FGPMZZLQSA-N
• SMILES: Cc1cc(=O)oc2cc(O[C@@H]3OC(CO)[C@H](O)C(O)C3O[C@@H]3OC(C)[C@H](OC(=O)c4ccccc4)C(OC(=O)c4ccccc4)C3OC(=O)c3ccccc3)ccc12