Product Information
Name:7-Azido-4-methylcoumarin
Controlled Product
Synonyms:
- 7-Azido-4-methyl-2H-1-benzopyran-2-one 4-Methyl-7-azidocoumarin
Brand:TRC
Description:Applications 7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine β-synthase (CBS), cystathionine γ-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine β-synthase (CBS) inhibitors and activators. The aromatic azide moiety is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with ?ex = 365 nm and ?em = 450 nm. It has been characterized as a novel fluorescent photoactive probe for use in photoaffinity labeling of the substrate binding site of human phenol sulfotransferase (SULT1A1 or P-PST-1)References Chen G, et al. Protein Sci. 1999 Oct;8(10):2151-7.Collom SL el al. Arch Biochem Biophys. 2007 Mar 1;459(1):59-69
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Chemical properties
Molecular weight:201.181
Formula:C10H7N3O2
Color/Form:Neat
InChI:InChI=1S/C10H7N3O2/c1-6-4-10(14)15-9-5-7(12-13-11)2-3-8(6)9/h2-5H,1H3
SMILES:Cc1cc(=O)oc2cc(N=[N+]=[N-])ccc12
Technical inquiry about: 7-Azido-4-methylcoumarin
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