A23187

CAS: 52665-69-7

Ref. TR-A965310

Product Information

• Name: A23187
• Synonyms: 5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic Acid, A 23187, Antibiotic A 23187, Calcimycin, Calcium ionophore A 23187, Calimycin, Ionophore A 23187, [6S-[6alpha(2S*,3S*),8beta(R*),9beta,11alpha]]-5-(Methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5,5]undec-2-yl]methyl]-4-benzoxazolecarboxylic Acid, 1,7-Dioxaspiro[5.5]undecane, 4-benzoxazolecarboxylic acid deriv., 4-Benzoxazolcarbonsaure, 5-(Methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-, 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[(2R,3R,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, 5-(Methylamino)-2-[[(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid, Calcium ionophore III, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-5-(Methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5,5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid, acide benzoxazolecarboxylique-4, (methylamino)-5 [[trimethyl-3,9,11 [methyl-1 oxo-2 (1H-pyrrolyl-2)2 ethyl]-8 dioxa-1,7 spiro[5.5]undecyl-2]methyl]-2, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-, acido 4-benzoxazolcarboxilico, 5-(metilamino)-2-[[3,9,11-trimetil-8-[1-metil-2-oxo-2-(1H-pirrol-2-il)etil]-1,7-dioxaespiro[5.5]undec-2-il]metil]-, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-, 4-Benzoxazolecarboxylic acid, 5-(methylamino)-2-[[3,9,11-trimethyl-8-[1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-, [6S-[6α(2S*,3S*),8β(R*),9β,11α]]-

Description

Applications A23187 is calcium channel modulator; Highly selective Ca2+ ionophore.
References Khin, P. P., et al.: Pharmacol., 99, 216-225 (2017); Han, N., et al.: Chin. Exp. Pharmacol. Physiol., 44, 257-265 (2017)

• Brand: TRC

Chemical properties

• Molecular weight: 523.62
• Formula: C₂₉H₃₇N₃O₆
• Color/Form: Neat
• InChI: InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
• InChI key: InChIKey=HIYAVKIYRIFSCZ-CYEMHPAKSA-N
• SMILES: CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(=O)O